Do you have unsubscribed email addresses from a previous email system or maintain your own list? You can easily add these to your JangoMail account. It's important that JangoMail knows we shouldn't send to these recipients.
In addition to manually adding an email address or domain to the Unsubscribe List, you can import a large list of unsubscribes into your account.
To import a file of unsubscribes, create a list and import your unsubscribes. Then use the list option under Remove, titled "Unsubscribe All Members". This will copy all the email addresses in the list into your account's global Unsubscribe List. You can then delete the list if you would like.